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Sydney Brenner Collection

Identifier: SB

Scope and Content

The Sydney Brenner Collection consists of over 300 manuscript boxes of materials documenting the life of Dr. Sydney Brenner, from his early years as a student in South Africa, his work as a scientist and administrator at the Medical Research Council (MRC), to his role in the biotechnology industry in the United States and United Kingdom.

The collection also includes material that belonged to Francis Crick and Leslie Barnett. The two shared offices with Brenner at the MRC beginning in the 1950s (Crick left in the mid-1970s and Barnett in the 1990s).

The second record group consists of material that was donated by Philip Goelet in 2023. This material was created during the time that Goelet and Brenner were involved in biotech ventures together, namely Acidophil and Dihedron. Some of the material relates directly to these companies, while others were simply produced in the same time period of 1991-2005 and stored together with the biotech material. The correspodence was arranged to match the organization of the correspondence in the first record group.

The first group has 13 series, and the second has five.

Record Group I

  1. Correspondence, 1946-2013
  2. Writings, 1947-2012
  3. Lectures, 1959-2010
  4. Subject Files, 1949-2013
  5. Personal Papers, 1952-2010
  6. Laboratory and Course Files, 1952-2010
  7. Reprints, 1934-2003
  8. Photographs, 1927-2008
  9. Articles and Clippings, 1939-2015
  10. Ephemera, 1949-2009
  11. Francis Crick, 1949-1982
  12. Leslie Barnett (Margaret Leslie Collard), 1963-1991
  13. Audiovisual, 1990-2013

Record Group II

  1. Correspondence, 1991-2005
  2. Writings, 1990-2004
  3. Acidophil and Dihedron, 1982-2005
  4. Personal Papers, 1991-2023
  5. Artifacts, 2004-2005

Please see the scope and content notes for each series for more detailed descriptions.


  • Creation: 1927 - 2023

Language of Materials

English (bulk)

Access Restrictions

Virtual access to most material from this collection is availabe freely online, via the Cold Spring Harbor Laboratory Digital Archives Repository.

Physical access is given only by appointment, 8:00a.m. to 4:45p.m., Monday through Friday. Certain restrictions to material apply to both virtual and physical collections. Contact archivist for details.

Use Restrictions

Archival materials may be used for research purposes only. Usage of material to support decisions about the person who is the subject of the material, or in a way that causes substantial damage or distress to them is prohibited. When visiting the physical repository, archival materials must remain in the archival reading area. Item duplication is to be done by archivists. Fees are applied to copies made. Digital photography is permitted by users. Due to the very fragile nature of some materials in this collection, some are available through photocopies; others must be used under the supervision of an archivist.


Sydney Brenner, British biologist/geneticist and winner of the 2002 Nobel Prize in Physiology or Medicine, was born in Germiston, South Africa in 1927. His parents were Jewish immigrants from Eastern Europe, his father from Lithuania and his mother from Latvia. Sydney's father was a cobbler, a vocation he would have throughout his entire life, and like many struggling families, the Brenner's lived on the premises of their business, occupying two rooms in the back of the shoe repair shop.

Young Sydney was taught how to read by the wife of a tailor who lived nearby, for his father could neither read nor write. When it was discovered that he was reading fluently at the age of four, he was sent to a kindergarten run by a Presbyterian church --- the only school his parents could afford to send him to. He quickly acquired a love of reading and learning. He discovered the world of books at the Carnegie built public library in Germiston, and read voraciously. He soon developed an interest in chemistry and biochemistry, and he conducted basic experiments he found in various books, such as The Young Scientist, by Sherwood Taylor. He quickly mastered his school subjects and graduated from Germiston High School at the age of 15.

With the aid of a small stipend from the Town Council from Germiston, Brenner was able to attend the University of the Witwatersrand in Johannesburg. For two years he studied the basic science courses in preparation for medical school. Realizing that he was too young to qualify for the practice of medicine, Sydney took additional courses in the Anatomy Department. During this period, he was able to observe advanced researchers like Alfred Oettle, Joel Mandelstam and Harold Daitz, and his interest in laboratory research flourished.

Brenner, by his own admission, was not a good medical student but he did manage to scrape by and receive the degrees of MB BCh in 1951. In July of that same year he announced that he would not pursue the practice of medicine. Instead, after being awarded a scholarship by the Commission for the Royal Exhibition of 1851, and on the advice of Sir Cyril Hinshelwood, Brenner applied for and was accepted at Oxford University where he was intent on pursuing a Ph.D. in the Physical Chemistry Laboratory.

In December of 1952 Brenner married in London. His wife, May, was able to move with him to Oxford where she pursued a Ph.D. in Psychology.

In April 1953, Jack Dunitz informed Brenner of the developments with the structure of DNA at the Cavendish Laboratory at Cambridge. Later that same month, Brenner, along with Dunitz and others, traveled to Cambridge to see the model first hand. It was there that Brenner met both Francis Crick and James D. Watson and first saw the famous double helix.

In November of 1953, Brenner wrote Dr. Milislav Demerec, then director of the Carnegie Institution Laboratory at Cold Spring Harbor, for approval to visit the Laboratory. Demerec responded, "You will be welcome to stay here as long as is convenient for you." On 24 November, 1953, Brenner applied for a Carnegie Corporation grant for travel and study in the United States. His stated intentions were to meet researchers in the fields of chemical microbiology, microbial genetics and virology; study the organization of laboratories and teaching methods; and to obtain strains of viruses and bacteria which were not available in South Africa, all of which he accomplished.

In July of 1954. Brenner arrived in the United States. He spent his first 2 1/2 months at the Laboratory in Cold Spring Harbor attending courses on bacteriophage and bacterial genetics while continuing experiments with the biosynthesis of tryptophan. There he met many of the people who played important roles in the development of the study of molecular biology including Seymour Benzer, Salvador Luria, and Max Delbruck.

Brenner made visits to several laboratories while in the United States, including extended visits to Cal Tech and the Kerckhoff Biological Laboratory, and he spent several weeks in the Virus Laboratory at the University of California. In California, he carried out research in the growth of bacteriophages in bacterial cells from which the cell walls had been removed.

In November of 1954, Brenner went to Great Britain and visited Francis Crick in Cambridge where, among other things, they discussed the possibility of working together in the future. However, he was obligated to return to South Africa where a staff appointment was waiting for him at the medical school. Brenner set up a laboratory in the Department of Physiology and he was awarded a grant to study phage co-factor genetics. During that period, he also worked on proving the impossibility of overlapping triplet codes. On 30 December, 1955, Francis Crick wrote, "Speedy progress. Himsworth has agreed that I may open informal negotiations with you for an appointment of limited tenure." Brenner accepted a three-year appointment at the Medical Research Council, which later became the MRC Laboratory of Molecular Biology, and in December of 1956 he and his family were on their way back to England.

In January of 1957, Brenner set about to build a laboratory dedicated to research in molecular genetics using bacteriophages and bacteria. Brenner, Crick, and their colleagues demonstrated, through mutations in E. coli, that the genetic code was made up of triplets of nucleotides (which Brenner named 'codons'). This research was followed by investigating the relationship of messenger RNA to DNA. Brenner and his colleagues determined that one of the mRNA sequences was a 'nonsense' codon that signaled the termination of protein synthesis.

Brenner is most noted for his investigation of genetic information and its development through his experiments with Caenorhabditis elegans. In October of 1963, he requested a culture of free-living nematodes, also known as C. elegans, from E. C. Dougherty at the University of California, Berkeley. He also asked for Dougherty's reprints on the organism and advice on how to propagate the males. Brenner began to work with the organisms that Dougherty sent, and wrote, "Thank you very much indeed for the culture of Caenorhabditis elegans. It arrived in good shape and I waited to write until I had done some work with it. I now have flourishing monoxenic cultures, and am about to try axenic cultures. It is an astounding organism." The nematode worm (C. elegans), with its simple structure and nervous system, was determined to be an ideal organism for study in developmental biology and neurobiology.

In 1977, Brenner was appointed the Director of the MRC Laboratory following the retirement of Max Perutz. Much of Brenner's tenure was spent with the typical administrative responsibilities so when the term of his appointment ended he left the MRC Laboratory to pursue research projects at a newly established research unit given to him by the MRC, as well as opportunities at other institutions. In addition, he began championing the establishment of genome projects, such as the C. elegans, which was the first organism to have its genome completely sequenced.

For his pioneering studies Brenner received many awards and honors during his career including the Albert Lasker Medical Research Award (1971), the Kyoto Prize (1990), and the Copley medal (1991), which is the oldest scientific award in the world. He received numerous honorary degrees from many colleges and universities, including the Universities of Oxford, Cambridge, Harvard, London, Glasgow, Chicago, and Witwatersrand, where his scientific career began. In 2002, the Nobel Prize in Physiology or Medicine was awarded jointly to Sydney Brenner, H. Robert Horvitz, and John E. Sulston, "for their discoveries concerning genetic regulation of organ development and programmed cell death."

Sydney Brenner published many articles during his career. In the 1990s he wrote a column called 'Loose Ends' for Current Biology, which often reflected his great intelligence and wit. In one particular 1996 column he wrote, "Watch this column in 2020 for revelations...," an accurately expressed statement of his endless passion for knowledge and discovery. His long and distinguished career as a scientist made him one of the principal contributors to the history of molecular biology.

Sydney Brenner died at the age of 92 on April 5, 2019 in Singapore, where he had helped develop scientific institutes. Sydney Brenner was widely regarded as the "father of biomedical sciences" in Singapore, as he was pivotal to the establishment of Singapore’s first life sciences research institute in 1985, the Institute of Molecular and Cell Biology, which was officially opened at the National University of Singapore (NUS) in 1987. He was an adjunct professor at the NUS Yong Loo Lin School of Medicine, and was conferred the Honorary Doctor of Letters in 1995 for his contributions to Singapore. Among other accolades he received for his dedication and commitment to Singapore were the Distinguished Friends of Singapore award in 2000, Honorary Citizen in 2003, and the National Science and Technology Medal in 2006.


484 Boxes : 201 Linear Feet


The Sydney Brenner Collection consists of over 300 manuscript boxes of materials documenting the life of Dr. Sydney Brenner, documenting his early years as a student in South Africa, to his work as a scientist and administrator at the Medical Research Council (MRC) and other institutions, to his role in the biotechnology industry in the United Kingdom.


The arrangement of the Sydney Brenner Collection is one that aims to maintain the original character of Brenner's personal filing system rather than to impose a new, artificial order. Dr. Brenner had two basic arrangements for his institutional papers: General institutional correspondence arranged alphabetically by author or organization, and significant groups of papers arranged by subject or organization, such as human genome, candidates, Celltech, Rothschild, and so forth. Manuscripts, lecture notes, and reprints could be found throughout the collection but were relocated into more logical series. Separation sheets were provided to indicate their original locations. Papers, photographs and ephemera in Brenner's possession but belonging to Francis Crick at one time were also kept in a separate location, and ultimately in their own series.


All of the items in the Sydney Brenner Collection were donated by Dr. Brenner to the Cold Spring Harbor Laboratory Archives in December of 2006. Brenner's collection of scientific books was donated in early 2007. A significant donation was made in 2010, and included Brenner's MRC Laboratory notebooks. Two additional small donations were made in 2014. The seven boxes comprising record group two were donated by Philip Goelet in 2023.

Related Collections

Related collections in the CSHL Library and Archive include the Sydney Brenner Book Collection and the Errol C. Friedberg Collection.

Researchers should note that additional Sydney Brenner material is located at the J. Craig Venter Institute in Collection MS 001 History of Molecular Biology (Norman) Collection. This collection contains research notes, typescripts, and reprints dating from 1956-1961. The Finding aid for this collection is available via Online Archives of California (OAC): J. Craig Venter Institute Archives MS001 Collection

After the Celebrating the Life and Science of Sydney Brenner meeting held at the Laboratory in March 2022, Library Director Mila Pollock asked participants to send their personal materials relating to Brenner to the Archives to be included in his collection. These materials are accessioned and categorized under the 'Sydney Brenner Memories' classification.

Sydney Brenner Collection
Original Finding Aid prepared by P.J. Novak (2007) and John Zarrillo (2010-2013). Stephanie Satalino (2013- )- Cold Spring Harbor Laboratory Archives. Record Group II added by Kate Pigliacelli in 2023.
Language of description
Script of description

Repository Details

Part of the Cold Spring Harbor Laboratory Archives Repository

Library & Archives
Cold Spring Harbor Laboratory
One Bungtown Rd
Cold Spring Harbor NY 11724 USA