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Molecular Clocks of Evolution, 1989-11-28 - 1989-12-01


Scope and Contents

The meeting Molecular Clocks of Evolution discussed how a considerable amount of data has been produced using differences in DNA between different species to measure the relatedness of species. Some of the data obtained using DNA as a molecular clock have required radical revision of previously accepted taxonomic relationships, and the purpose of this meeting was to examine whether the assumptions underlying the use of molecular clocks are justified. Data was presented with time scales measured in millions of years rather than the minutes or hours of conventional molecular biological data.


  • Creation: 1989-11-28 - 1989-12-01


Access Restrictions

Portions of this collection have been digitized and are available in full at CSHL Archives thanks to support from CLIR Recordings at Risk Grant awarded in 2021. Some restrictions apply, see Archivist for details. Access is given by appointment only.


8 Cassettes : Tape 1 Side 1 [00:47:10] Tape 1 Side 2 [00:47:11]; Tape 2 Side 1 [00:44:53] Tape 2 Side 2 [00:38:40]; Tape 3 Side 1 [00:46:59] Tape 3 Side 2 [00:46:59]; Tape 4 Side 1 [00:47:14] Tape 4 Side 2 [00:47:14]; Tape 5 Side 1 [00:46:50] Tape 5 Side 2 [00:46:50]; Tape 6 Side 1 [00:47:07] Tape 6 Side 2 [00:47:07]; Tape 7 Side 1 [00:46:06] Tape 7 Side 2 [00:46:14]; Tape 8 Side 1 [00:45:01] Tape 8 Side 2 [00:45:00]

Language of Materials

From the Collection: English

Session 1: Paleontological Calibration of Critical Taxonomic Branch Points with Particular Reference to Molecular Data

Geological Dating and Molecular Clocks / Louis Jacobs


Calibrations of Ancient Vertebrate Origins / Everett Olson


Origin of the Multicellular Animals / James Lake


Using Molecular and Morphological Evolutionary Rates to Study Evolutionary Processes in a Group of Mammals / Elisabeth Vrba


General Discussion / Ernst Mayr

Session 2: Specific Applications of Molecular Clocks

Molecular Evolutionary Clocks of Viral Genes / Takashi Gojobori


Phylogenetic Invariants and the Echinodermata / Richard Holmquist


Molecular Clocks and Mammalian Phylogeny / Wen-Hsiung Li


General Discussion / Vincent Sarich

Session 3: Rate Variation Within and Between Genomes

Intragenomic Heterogeneity in Rates of DNA Evolution in Drosphilia / Jeffrey Powell


Roy Britten


Evidence for Unequal Rates of DNA Evolution in Primates / Tom Bronner


Nearly Neutral Mutations and the Molecular Clock / Tomoko Ohta


General Discussion / Thomas Jukes

Session 4: The Effects of Selection on Rates of Molecular Evolution

When Do Clocks Go Wrong? How Often? How Badly? / Walter Fitch


Darwinian Evolution and the Acceleration/Deceleration Pattern in Rates of Mutation and Fixation / Morris Goodman


The Effects of Natural Selection on Nucleotide Polymorphism / Margaret Riley


Effects of Positive and Negative Darwinian Selection on Molecular Clocks: Data from the MHC and Immunoglobulin Families / Masatoshi Nei


General Discussion / Emile Zuckerkandl

Session 5: Molecular Consequences of Behavior, Demography, and Biogeography

Hybridization of Species may Confound the Molecular Clock / Hampton Carson


Biogeography and Molecular Clocks / Rob DeSalle


Rapid Rates of Molecular Change as a Consequence of Behavior and Biogeography / Don Melnick


General Discussion / Francisco Ayala

Repository Details

Part of the Cold Spring Harbor Laboratory Archives Repository

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