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The Molecular Biology of Alzheimer's Disease, 1988-04-24 - 1988-04-27

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Scope and Contents

The Molecular Biology of Alzheimer's Disease meeting showed that research on this disease is at a more satisfactory stage. This meeting included a remarkable group of studies ranging from neuroanatomical genetics, through protein chemistry, to molecular genetics. In a particularly exciting session, it was shown that p-amyloid protein is not a constituent of the paired helical filaments that accumulate in the tangles and plaques that are characteristic of Alzheimer's disease. In addition to evaluating data, meeting participants discussed the ethics of performing early autopsies to obtain brain samples from patients. The overwhelming consensus of the participants was that these procedures are ethical and provide invaluable data.

Dates

  • Creation: 1988-04-24 - 1988-04-27

Creator

Conditions Governing Access

Tapes have been digitized and are available for research in person at CSHL Archives.

Extent

10 Cassettes : Tape 1 Side 1 [00:30:56] Tape 1 Side 2 [00:30:56]; Tape 2 Side 1 [00:45:41] Tape 2 Side 2 [00:45:41]; Tape 3 Side 1 [00:30:37] Tape 3 Side 2 [00:30:37]; Tape 4 Side 1 [01:00:47] Tape 4 Side 2 [01:00:47]; Tape 5 Side 1 [00:30:39] Tape 5 Side 2 [00:30:34]; Tape 6 Side 1 [00:30:37] Tape 6 Side 2 [00:30:38]; Tape 7 Side 1 [01:00:28] Tape 7 Side 2 [01:00:36]; Tape 8 Side 1 [01:00:50] Tape 8 Side 2 [01:00:50]; Tape 9 Side 1 [01:00:28] Tape 9 Side 2 [01:00:27]; Tape 10 Side 1 [01:00:45] Tape 10 Side 2 [00:56:18]

Language of Materials

From the Collection: English

Additional Description

Session 1: Neurochemistry and Neuroanatomy

Absense of Both Hypometaolism and Widespread Loss of Pyramidal Neurons Antemortem? / David M. Bowen

Further Studies of A68 / Peter Davies

Cloning for mRNA That Have Regionally Selective Alterations in Alzheimer's Disease / Caleb E. Finch

Nerve Growth Factor Reestablishes Several Cholinergic Pathways: Implications for Alzheimer's Disease / Franz Hefti

An Animal Model For Studies of Down Syndrome and Alzheimer's Disease / Roger Reeves

Brain Evolution and Alzheimer's Disease / Stanley I. Rapoport

Growth-associated Protein (GAP-43) in Alzheimer's Disease / Paul Coleman

Effects of NGF on Cholinergic Neurons in the Central Nervous System / Fred H. Gage

Immune System Response in Alzheimer's Disease / Patrick L. McGear

Neuroimmunology of Alzheimer's Disease / Joseph Rogers

Neuronal Specificity in Alzheimer's Disease / Carol A. Miller

The Cellular, Laminar, and Regional Distribution of Neurofilament Protein and Amyloid-B-Protein mRNA in Neocortex: Implications for Alzheimer's Disease Pathology / John H. Morrison

Alzheimer's Disease and Animal Models / Donald L. Price

Session 2: Molecular Biology of Plagues and Tangles

Alzheimer's Disease and the Amyloid Gene Product / Konrad Beyreuther

Dmitry Goldgaber

In Situ Hybridization of Amyloid-B-Protein mRNA Transcripts in the Hippocampal Formation in Alzheimer's Disease / Gerald A. Higgins

B-Amyloid Gene Expression and Cellular Localization in AD Brain / Steven A. Johnson

Molecular Basis of Amyloidosis in Alzheimer's Disease / Colin L. Masters

The Precursor of Azheimer's Disease A4 Protein / Benno Muller-Hill

Expression of Alzheimer Amyloid Precursor Messenger RNAs in the Developing Adult Brain / Rachael L. Neve

B-Amyloid Precursor Proteins: Regional CNS Processing and Comparison of PHF-Related Proteins / Dennis J. Selkoe

Molecular Genetics Analysis of the APP Gene / Rudolph Tanzi

Beta Peptide Precursor Protein Producing and Processing Cells / Henry M. Wisniewski

Structure and Biochemistry of the Alzheimer Tangle / Aaron Klug

Untangling the Insoluable: A CHaracterization of Alzheimer's Paired Helical Filaments / Gary Dean

Session 3: Genetics

The Formation of Brain Amyloids; Molecular Genetics of Neurodegradation - The Prion Model / Stanley B. Prusiner

Contribution of Analytic Epidemiology to the Molecular Biology of Alzheimer's Disease / Luigi A. Amaducci

The Clinical and Neuropathological Spectrum of Familial Alzheimer's Disease in 24 Kindreds / Thomas D. Bird

Familial Aggregation of Alzheimer's Disease: Implications for Genetic Models / Richard C. Mohs

Linkage in Late Onset Alzheimer's Disease / Allen D. Roses

Molecular Genetics of Sporadic and Familial Alzheimer's Disease / Pater H. St. George-Hyslop

Repository Details

Repository Details

Part of the Cold Spring Harbor Laboratory Archives Repository

https://www.cshl.edu/archives/
Contact:
Library & Archives
Cold Spring Harbor Laboratory
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Cold Spring Harbor NY 11724 USA
516-367-6872