Nongenotoxic Mechanisms in Carcinogenesis, 1986-04-13 - 1986-04-16
File
Scope and Contents
This meeting examined the multitude of ways in which known carcinogens interact with cells, apart from their effects on DNA. The most complex problem is to distinguish between the primary and secondary effects of carcinogens. Clearly, this aspect of research will continue to require further intensive study before definitive answers can be obtained.
Dates
- Creation: 1986-04-13 - 1986-04-16
Creator
- Barrett, J. Carl (Person)
- Boreiko, Craig J. (Person)
- Brand, K. Gerhard (Person)
- Butterworth, Byron E. (Person)
- Cerutti, Peter A. (Person)
- Cohen, Samuel M., 1946- (Person)
- Coombs, Maurice M. (Person)
- Diamond, Leila (Person)
- DiGiovanni, John (Person)
- Ghoshal, Amiya (Person)
- Greenlee, William F. (Person)
- Heck, Henry d'A. (Person)
- Loury, David J. (Person)
- Magee, Peter N. (Person)
- Newberne, Paul M., 1920- (Person)
- Parzefall, Wolfram (Person)
- Pitot, Henry C., 1930- (Person)
- Reitz, Richard H. (Person)
- Roe, Francis J.C. (Person)
- Rosenkranz, Herbert S. (Person)
- Sarma, Dittakavi S.R. (Person)
- Scribner, Harvey E. (Person)
- Sivak, Andrew (Person)
- Slaga, Thomas J. (Person)
- Stevenson, Donald E. (Person)
- Swenberg, James A. (Person)
- Tennant, Raymond W. (Person)
- Trump, Benjamin F. (Person)
- Wachsmuth, Ernst Dieter (Person)
- Weinstein, I. Bernard , 1930-2008 (Person)
- Williams, Gary M. (Person)
- Yamasaki, Hiroshi (Person)
Conditions Governing Access
Tapes have been digitized and are available for research in person at CSHL Archives.
Extent
9 Cassettes : Tape 1 Side 1 [00:45:38]; Tape 1 Side 2 [00:45:39]; Tape 2 Side 1 [00:45:48]; Tape 2 Side 2 [00:45:45]; Tape 3 Side 1 [01:00:29] Tape 3 Side 2 [01:00:29]; Tape 4 Side 1 [00:46:12]; Tape 4 Side 2 [00:46:11]; Tape 5 Side 1 [01:00:51]; Tape 5 Side 2 [01:00:55]; Tape 6 Side 1 [00:46:03]; Tape 6 Side 2 [00:46:08]; Tape 7 Side 1 [00:45:59]; Tape 7 Side 2 [00:45:59]; Tape 8 Side 1 [00:39:02]; Tape 8 Side 2 [00:26:19]; Tape 9 Side 1 [00:39:36]; Tape 9 Side 2 [00:07:25]
Language of Materials
From the Collection: English
Session 1: Promotion
Tumor Promotion and Progression in the Mouse Skin Model / John F. O'Connell, Joel B. Rotstein, and Thomas J. Slaga
Studies on the Skin Tumor Promoting Actions of Chrysarobin / John DiGiovanni, Francis A. Kruszewski, and Kristine J. Chenicek
Multistage Carcinogenesis of the Rat Hepatocyte / Henry C. Pitot, David G. Beer, and Suzanne Hendrich
Bladder Tumor Promotion / Samuel M. Cohen, Leon B. Ellwein, and Sonny L. Johansson
Cell Injury, Ion Regulation, and Tumor Promotion / Benjamin F. Trump and Irene K. Berezesky
Studies on the Skin Tumor Promoting Actions of Chrysarobin / John DiGiovanni, Francis A. Kruszewski, and Kristine J. Chenicek
Multistage Carcinogenesis of the Rat Hepatocyte / Henry C. Pitot, David G. Beer, and Suzanne Hendrich
Bladder Tumor Promotion / Samuel M. Cohen, Leon B. Ellwein, and Sonny L. Johansson
Cell Injury, Ion Regulation, and Tumor Promotion / Benjamin F. Trump and Irene K. Berezesky
Session 2: Forced Cell Proliferation
Orotic Acid, a Novel Liver Tumor Promoter: Studies on Its Mechanism of Action / Ezio Laconi, Shanthi Vasudevan, Prema M. Rao, Srinivasan Rajalakshmi, and Dittakavi S.R. Sarma
Role of Stimulation of Liver Growth by Chemicals in Hepatocarcinogenesis / Rolf Schulte-Hermann, Wolfram Parzefall, and Wilfried Bursch
Role of Cytotoxicity in the Carcinogenic Process / Richard H. Reitz
The Value of Measuring Cell Replication as a Predictive Index of Tissue-specific Tumorigenic Potential / David J. Loury, Thomas L. Goldsworthy, and Byron E. Butterworth
Chemically Induced Cell Turnover in the Kidney and Its Possibe Role in Carcinogenesis / Ernst D. Wachsmuth
Influence of Cytotoxicity on the Induction of Tumors / James A. Swenberg and Brian G. Short
Role of Stimulation of Liver Growth by Chemicals in Hepatocarcinogenesis / Rolf Schulte-Hermann, Wolfram Parzefall, and Wilfried Bursch
Role of Cytotoxicity in the Carcinogenic Process / Richard H. Reitz
The Value of Measuring Cell Replication as a Predictive Index of Tissue-specific Tumorigenic Potential / David J. Loury, Thomas L. Goldsworthy, and Byron E. Butterworth
Chemically Induced Cell Turnover in the Kidney and Its Possibe Role in Carcinogenesis / Ernst D. Wachsmuth
Influence of Cytotoxicity on the Induction of Tumors / James A. Swenberg and Brian G. Short
Session 3: Rodent Bioassays
Nongenotoxic Mouse Liver Carcinogens / Paul M. Newberne, Vore Suphakarn, Phaibul Punyarit, and Joao de Camargo
Induction of Cancer by Dietary Deficiency without Added Carcinogens / Amiya Ghoshal, Thomas Rushmore, and Emmanuel Farber
The Problem of Pseudocarcinogenicity in Rodent Bioassays / Francis J.C. Roe
Induction of Cancer by Dietary Deficiency without Added Carcinogens / Amiya Ghoshal, Thomas Rushmore, and Emmanuel Farber
The Problem of Pseudocarcinogenicity in Rodent Bioassays / Francis J.C. Roe
Session 4: Solid State Carcinogens
Solid State Carcinogens / K. Gerhard Brand
Biogenic Silica Fibers and Skin Tumor Promotion / Tarlochan Bhatt, Maurice Coombs, and Charles O'Neill
Bladder Stones and Bladder Cancer: A Review of the Toxicology of Terephthalic Acid / Henry d'A. Heck
Biogenic Silica Fibers and Skin Tumor Promotion / Tarlochan Bhatt, Maurice Coombs, and Charles O'Neill
Bladder Stones and Bladder Cancer: A Review of the Toxicology of Terephthalic Acid / Henry d'A. Heck
Session 5: Examples of Nongenotoxic Carcinogens
TCDD: Mechanisms of Altered Growth Regulation in Human Epidermal Keratinocytes / William F. Greenlee, Rosemarie Osborne, Karen M. Dold, Lisa Ross, and Jon C. Cook
Genetic Toxicology of Di(2-ethylhexyl)phthalate / Byron E. Butterworth
The Mechanism of Urinary Tract Tumorigenesis of Nitrilotriacetate / Robert L. Anderson
Genetic Toxicology of Di(2-ethylhexyl)phthalate / Byron E. Butterworth
The Mechanism of Urinary Tract Tumorigenesis of Nitrilotriacetate / Robert L. Anderson
Session 6: Cell Culture Models
Modulation of Transformed Focus Formation in Cultures of C3H/10T1/2 Cells / Craig J. Boreiko
The Role of Cell-to-Cell Communication in Tumor Promotion / Hiroshi Yamasaki
Genetic and Epigenetic Mechanisms of Presumed Nongenotoxic Carcinogens / J. Carl Barrett, Mitsuo Oshimura, Noriho Tanaka, and Takeki Tsutsui
Genotoxic Oxidant Tumor Promoters / Peter A. Cerutti
The Role of Cell-to-Cell Communication in Tumor Promotion / Hiroshi Yamasaki
Genetic and Epigenetic Mechanisms of Presumed Nongenotoxic Carcinogens / J. Carl Barrett, Mitsuo Oshimura, Noriho Tanaka, and Takeki Tsutsui
Genotoxic Oxidant Tumor Promoters / Peter A. Cerutti
Session 7: Regulatory Considerations
Some Implications and Limitations of In Vitro Genetic Toxicity Data in Regulatory Decisions / Raymond W. Tennant
Practical Approaches to Evaluating Nongenotoxic Carcinogens / Harvey E. Scribner, Kay L. McCarthy, and David J. Doolittle
Definition of a Human Cancer Hazard / Gary M. Williams
Concluding Discussion
Author Index
Subject Index
Practical Approaches to Evaluating Nongenotoxic Carcinogens / Harvey E. Scribner, Kay L. McCarthy, and David J. Doolittle
Definition of a Human Cancer Hazard / Gary M. Williams
Concluding Discussion
Author Index
Subject Index
Repository Details
Part of the Cold Spring Harbor Laboratory Archives Repository
Contact:
Library & Archives
Cold Spring Harbor Laboratory
One Bungtown Rd
Cold Spring Harbor NY 11724 USA
516-367-6872
archives@cshl.edu
Library & Archives
Cold Spring Harbor Laboratory
One Bungtown Rd
Cold Spring Harbor NY 11724 USA
516-367-6872
archives@cshl.edu