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Ethylene Dichloride: Economic Importance and Potential Health Risks, 1979-11-14 - 1979-11-17

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Scope and Contents

Examination at the conference of the manufacture and uses of this major chemical industry intermediate, of which some 10 billion pounds is manufactured annually in the United States and most of which is converted to vinyl chloride monomer, showed that although there is a high volume of potential exposures to ethylene dichloride, largely within the chemical industry, the level of exposure is low from the industry point of view, whereas it is worrisome to researchers studying the mutagenicity of the compound (who hold that the ambient air levels likely to be inhaled by workers match up with levels sufficient to induce cancer in laboratory animals). The conference explored variations in the results of carcinogenicity tests on ethylene dichloride and other chlorinated hydrocarbons, particularly between tests by tube-feeding and by inhalation of ethylene dichloride. It also considered new information on the effects of metabolism and binding of chlorinated hydrocarbons in cells and animals, and also of age, on the outcome of short-term tests of the mutagenicity of such compounds. Leading in the organization of the conference were Bruce Ames and Kim Hooper of the University of California at Berkeley, Peter Infante of the Occupational Safety and Health Administration, and Richard Reitz of the Dow Chemical Company.

Dates

  • Creation: 1979-11-14 - 1979-11-17

Creator

Conditions Governing Access

Tapes have been digitized and are available for research in person at CSHL Archives.

Extent

9 Cassettes : Tape 1 Side 1: [0:45:49] Tape 1 Side 2: [0:45:49]; Tape 2 Side 1: [0:45:51] Tape 2 Side 2: [0:41:02]; Tape 3: [0:40:01]; Tape 4 Side 1: [0:42:56] Tape 4 Side 2: [0:11:29]; Tape 5 Side 1: [0:42:40] Tape 5 Side 2: [0:40:34]; Tape 6 Side 1: [0:41:45] Tape 6 Side 2: [0:42:41]; Tape 7 Side 1: [0:43:47] Tape 7 Side 2: [0:40:06]; Tape 8 Side 1: [0:44:01] Tape 8 Side 2: [0:38:23]; Tape 9: [0:14:17]

Language of Materials

From the Collection: English

Session 1: Mutagenicity and Carcinogenicity of Ethylene Dichloride

Long-Term Carcinogenic Bioassays on Ethylene Dichloride Administered by Inhalation to Rats and Mice / Cesare Maltoni, Loretta Valgimigli, and Corrado Scarnato
The Carcinogenicity of Ethylene Dichloride in Osborne-Mendel Rats and B6C3F1 Mice / Jerrold M. Ward
Carcinogenic Potency: A Progress Report / Bruce N. Ames, Kim Hooper, Charles B. Sawyer, Richard Peto, William Havender, Lois Swirsky Gold, Robert H. Harris, and Margaret Rosenfeld
The Carcinogenic Potency of Ethylene Dichloride in Two Animal Bioassays: A Comparison of Inhalation and Gavage Studies / Kim Hooper, Lois Swirsky Gold, and Bruce N. Ames
The Use of Different Metabolizing Systems in the Elucidation of the Mutagenic Effects of Ethylene Dichloride in Salmonella / Ulf Rannug
Review of Nonbacterial Tests of the Genotoxic Activity of Ethylene Dichloride / Vincent F. Simmon

Session 2: Toxicology and Other Topics

Pharmacokinetics of Ethylene Dichloride in Rats Treated by Different Routes and Its Long-Term Inhalatory Toxicity / Federico Spreafico, Ettore Zuccato, Franca Marcucci, Marina Sironi, Silvio Paglialunga, Margherita Madonna, and Emilio Mussini
Pharmacokinetics and Macromolecular Interactions of Ethylene Dichloride: Comparisons of Oral and Inhalation Exposures / Richard H. Reitz, Tony R. Fox, Jeanne Y. Domoradzki, John F. Quast, Pat Langvardt, and Phillip G. Watanabe
Teratogenicity and Reproduction Studies in Animals Inhaling Ethylene Dichloride / K. Suryanarayana Rao, Janis S. Murray, Mary M. Deacon, Jacqueline A. John, Linda L. Calhoun, and John T. Young
An Investigation of Possible Sterility and Health Effects from Exposure to Ethylene Dibromide / Gary Ter Haar
Carcinogenicity and Metabolism of Some Halogenated Olefinic and Aliphatic Hydrocarbons / Benjamin L. Van Duuren

Session 3: Uses of Ethylene Dichloride: Worker Exposure

Human Exposures to Ethylene Dichloride / Lois Swirsky Gold
Production, Uses, and Environmental Fate of Ethylene Dichloride and Ethylene Dibromide / Lawrence Fishbein
Use and Air Quality Impact of Ethylene Dichloride and Ethylene Dibromide Scavengers in Leaded Gasoline / Emmett S. Jacobs
Medical Aspects of Ethylene Dichloride in the Workplace / Maurice N. Johnson
Human Exposure to Ethylene Dichloride: Potential for Regulation via EPA's Proposed Airborne Carcinogen Policy / Robert G. Kellam and Michael G. Dusetzina

Session 4: Related Chemicals

Dietary Disulfiram Enhancement of the Toxicity of Ethylene Dibromide / Harry B. Plotnick, Walter W. Weigel, Donald E. Richard, Kenneth L. Cheever, and Choudari Kommineni
Evidence for the Carcinogenicity of Selected Halogenated Hydrocarbons Including Ethylene Dichloride / Peter F. Infante and Patricia B. Marlow
Evidence of the Mutagenicity of Ethylene Dichloride and Structurally Related Compounds / Jill D. Fabricant and John H. Chalmers, Jr.
Metabolism of 1,2-Dihaloethanes / Marion W. Anders and John C. Livesey
Summary / Robert K. Hinderer
Appendix

Repository Details

Part of the Cold Spring Harbor Laboratory Archives Repository

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