Skip to main content

Mario Capecchi, 2010-10-27

 Item — Multiple Containers

Scope and Contents

From the Collection:

The Oral History Collection contains interviews conducted with 200 scientists within the fields of molecular biology, genetics, and the life sciences between 1990 and 2018. The interviewees provide first-hand accounts of their experiences in the fields of modern biology, such as neuroscience, cancer, genetics, plant genetics, genomics, biotechnology and others, from the 1940s through the 2000s. The collection contains audio and video recordings, as well as transcripts of interviews.

The interviews offer a glimpse into the life of prominent scientists. The interviews discuss scientists' early school days and beginning interests in science to what or who made them choose to go into science. They also include reminiscences about their research and major discoveries, experiences of women in science, the character and life of leading scientists like Barbara McClintock and James D. Watson, the history of Cold Spring Harbor Laboratory, the nature of the double-helix discovery, the ethics of the Human Genome Project and biotechnology.

Many scientists interviewed for this project have either carried out their research or attended scientific meetings at Cold Spring Harbor Laboratory. Their recollections document not only the history of molecular biology and genetics the but also the laboratory's role in this history. The collection comprises of Hi8 8mm tapes; mini-DV; DVCAM and VHS audio cassette tapes. Most of the interviews from this collection have been transcribed. Interviews which have been digitized can be found at the Oral History Collection page.

The collection is organized into two series: Talking Science Interviews and Presentations. Talking Science Interviews consist of individual scientists, while the Presentations series include clips of oral history interviews that were used for a specific meeting or event.
From the Collection:

From the Collection:
  1. Talking Science Interviews, 1990-2017
  2. Presentations, 2016-2019

Dates

  • Creation: 2010-10-27

Creator

Conditions Governing Access

Portions of this collection have been digitized and are available online: https://library.cshl.edu/oralhistory/. Select tapes have been digitized thanks to support from CLIR Recordings at Risk Grant awarded in 2021, these tapes are available for research online via our Oral History Website and in person at CSHL Archives. Please contact CSHL Archives archives@cshl.edu with any questions regarding availability.

Biographical / Historical

Mario R. Capecchi, Ph.D., is a scientist and a Howard Hughes Medical Institute investigator at the Eccles Institute of Human Genetics at the University of Utah Health Sciences Center and a founding member of the Brain Institute at the University of Utah. He also serves as the Distinguished Professor and Co-Chairman of Human Genetics and Biology at the University of Utah, where he joined the faculty in 1973.

In 2007 Mario Capecchi was awarded the Nobel Prize in Medicine with Oliver Smithies and Martin Evans for their research on gene targeting techniques, specifically working with mice embryo-derived stem cells. In the 1980s Capecchi pioneered a technology known as "knockout mice" which revolutionized genetic and biomedical research. This technology allows scientists to replace or disrupt specific genes in mice to understand how a similar gene disruption in humans may cause or contribute to diseases.

Capecchi, abandoned and homeless as a 4-year old child in Italy during World War II, was reunited with his mother and immigrated to the United States in 1946. After receiving a B.S. in physics and chemistry from Antioch College in 1961, he joined Jim Watson's Biological laboratory at Harvard University where he received a doctorate in biophysics in 1967. Capecchi remained at Harvard, first as a junior fellow until 1969, followed by four years as Assistant Professor in the Department of Biochemistry at Harvard School of Medicine, until he left for the University of Utah in 1973.

Capecchi is a member of the National Academy of Sciences (1991) and the European Academy of Sciences (2002). His other numerous honors include the Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1992), Gairdner Foundation International Award for Achievements in Medical Science (1993), General Motors Corporation's Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contributions to Cancer Research (1994), Kyoto Prize in Basic Sciences (1996), the Franklin Medal for Advancing Our Knowledge of the Physical Sciences (1997), the University of Utah's Rosenblatt Prize for Excellence (1998), the Albert Lasker Award for Basic Medical Research (2001), the National Medal of Science (2001), the Wolf Prize in Medicine (2003), the Pezcoller Foundation-AACR (American Association for Cancer Research) International Award for Cancer Research (2003), and the March of Dimes Prize in Developmental Biology (2005).

Extent

2 Cassettes (Camcorder footage) : MiniDV - CSHL1030, CSHL1031

Language of Materials

From the Collection: English

Physical Storage Information

Repository Details

Repository Details

Part of the Cold Spring Harbor Laboratory Archives Repository

https://www.cshl.edu/archives/
Contact:
Library & Archives
Cold Spring Harbor Laboratory
One Bungtown Rd
Cold Spring Harbor NY 11724 USA
516-367-6872