Albertini, Richard J.

Scope and Contents The conference heard new evidence concerning such mammalian cell systems as the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovaries (CHO) and the thymidine kinase (TK)locus in mouse lymphoma cells, which revealed that mutations can be experimentally induced and quantitatively analyzed. Unresolved questions were also explored, such as the actual range of mutational events being assayed and whether the events in cell culture reflect the cellular responses...